GLP-1 medications have transformed the conversation around weight management. If you've heard about semaglutide (Wegovy, Ozempic) or tirzepatide (Zepbound, Mounjaro) from friends, social media, or the news, you're not alone—these medications have become some of the most talked-about treatments in healthcare.
But popularity doesn't mean these medications are right for everyone. Before starting any weight loss medication, it's important to understand how they work, what to realistically expect, and why working with a qualified medical provider makes all the difference.
In this guide, we'll walk through everything you should know before starting GLP-1 therapy—straight from the perspective of medical providers who prescribe and monitor these treatments every day.
How GLP-1 Medications Work in Your Body
GLP-1 stands for glucagon-like peptide-1, a hormone your body naturally produces in response to eating. This hormone plays several important roles:
- Signals fullness to your brain: GLP-1 tells your brain you've eaten enough, reducing appetite and the mental preoccupation with food many people experience.
- Slows stomach emptying: Food stays in your stomach longer, helping you feel satisfied with smaller portions.
- Regulates blood sugar: GLP-1 helps your body manage insulin and glucose levels, which is why these medications were originally developed for type 2 diabetes.
GLP-1 medications are synthetic versions of this hormone that last much longer in your body than the natural version. This sustained effect helps address the biological factors that make weight loss so difficult for many people.
Understanding Your Options: Semaglutide vs. Tirzepatide
While all GLP-1 medications work through similar mechanisms, there are important differences between the main options:
Semaglutide (Wegovy, Ozempic)
Semaglutide was the first GLP-1 medication approved specifically for weight loss (as Wegovy). It works purely as a GLP-1 receptor agonist. Available as a weekly injection, and as of January 2026, also available in a daily oral form. Clinical trials showed average weight loss of 15-17% of body weight over 68 weeks.
Tirzepatide (Zepbound, Mounjaro)
Tirzepatide is a "dual agonist" that targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. This dual action may provide enhanced effects for some patients. Available as a weekly injection. Clinical trials showed average weight loss of 18-22% of body weight, potentially making it more effective for some individuals.
Important note: "More effective" doesn't mean "better for everyone." Your provider will help determine which medication—if any—is most appropriate based on your specific health profile, medical history, and goals.
Who Is a Good Candidate for GLP-1 Medications?
GLP-1 medications are prescription treatments intended for specific populations. Generally, you may be a candidate if:
- You have a BMI of 30 or higher (obesity)
- You have a BMI of 27 or higher with at least one weight-related health condition (such as high blood pressure, type 2 diabetes, or high cholesterol)
- You've tried lifestyle modifications (diet and exercise) without achieving sustainable results
- You're committed to making lifestyle changes alongside medication
GLP-1 medications may NOT be appropriate if you:
- Have a personal or family history of medullary thyroid carcinoma (MTC)
- Have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Have a history of pancreatitis
- Are pregnant, planning to become pregnant, or breastfeeding
- Have certain gallbladder or kidney conditions
This is why a thorough medical evaluation is essential before starting treatment. A qualified provider will review your complete health history to ensure these medications are safe for you.
→ Not sure if you're a candidate? Schedule a consultation at Skën Med Spa's Arlington, VA or Lakewood, CO location. We'll review your health history and help you understand your options—with no pressure or obligation.
What to Expect: Side Effects, Timeline, and Results
Common Side Effects
Most side effects are gastrointestinal and tend to improve as your body adjusts to the medication:
- Nausea (most common, especially during dose increases)
- Vomiting or diarrhea (usually temporary)
- Constipation (staying hydrated helps)
- Fatigue or headaches (often improve within weeks)
- Injection site reactions (for injectable forms)
Pro tip: Most providers start with a low dose and gradually increase over several weeks. This "titration" process helps minimize side effects while allowing your body to adjust.
Realistic Timeline
- Weeks 1-4: You may notice reduced appetite and early changes in how you relate to food. Weight loss is often modest during the titration phase.
- Months 2-6: Most patients see significant, steady weight loss during this period as they reach therapeutic doses.
- Months 6-12+: Weight loss typically continues but may slow. This is when the focus shifts to maintenance and establishing sustainable habits.
- Months 12+: Long-term success depends on continued medication use and/or maintained lifestyle changes. Studies show that stopping medication without lifestyle modifications often leads to weight regain.
Why Medical Supervision Matters
You may have seen GLP-1 medications offered through telehealth services, online pharmacies, or even compounding pharmacies. While convenient access sounds appealing, there are important reasons to work with a qualified in-person provider:
- Thorough health assessment: A comprehensive evaluation catches contraindications that online questionnaires might miss.
- Personalized dosing: Your provider can adjust your treatment based on how you respond—something algorithms can't replicate.
- Side effect management: When issues arise, having a provider who knows your history makes all the difference.
- Medication authenticity: Compounded versions of these medications aren't FDA-approved and may vary in quality and efficacy.
- Integrated care: Weight management is most successful when combined with nutritional guidance, accountability, and long-term planning.
At Skën Med Spa, we provide personalized GLP-1 protocols that include regular check-ins, dose adjustments, and ongoing support. We're invested in your long-term success—not just writing prescriptions.
Questions to Ask Your Provider
Before starting GLP-1 therapy, consider asking:
- Based on my health history, which medication would you recommend and why?
- What side effects should I watch for, and when should I contact you?
- What's the titration schedule, and how long until I reach the full dose?
- How often will we check in during treatment?
- What lifestyle changes should I make alongside the medication?
- What's the plan if I want to stop the medication eventually?
- What's the total cost, and does insurance cover any of it?
Taking the Next Step
GLP-1 medications can be a powerful tool for people who've struggled with weight management despite their best efforts. But they're not a magic solution—they're most effective as part of a comprehensive approach that includes lifestyle changes, medical supervision, and realistic expectations.
If you're considering medical weight management, the most important step is having an honest conversation with a provider who can evaluate your unique situation. The right treatment plan—whether it includes medication or not—is the one that's safe, sustainable, and aligned with your goals.
Ready to learn more? Schedule a free weight loss consultation at Skën Med Spa. Our experienced providers will review your health history, discuss your options, and help you make an informed decision—no pressure, no obligation.
